If you have been on chat the past days you might have heard talk about adventure mode, or an extended quest system. Here I will describe what we are currently thinking that the Adventure Mode should be:
Adventure mode will be a seperate game mode, which you can access from the main menu. In this game mode, your card pool and even stats will be different from the rest of the game. What cards you have on your account will have no meaning in Adventure mode. In adventure mode you will start with a small card pool, and instead of gaining new cards one by one somewhat randomly as normally, you will unlock the use of new cards by completing quests. Quests will be all that exists in Adventure mode, and the quests will follow a main story. As you continue through the quests you will become stronger, both through increase in stats, as well as unlocking new cards. The unlocks will be static, and not random in any way (but there might exist choice sometimes on which reward you win).
As you can see Adventure mode will be like a seperate game, with little connection to the rest of the game. But this does not mean quests will disappear from the "main game". When you have completed a quest (or possible an area) in Adventure mode, you unlock that quest in the "normal" quest mode. In normal quest mode you will have access to your normal card pool, just like quest mode is right now. The quest in normal quest mode will be slightly different than when you completed it in Adventure mode though, consider it like a "hard mode". The quest could now have a more difficult deck, maybe more upgraded cards or higher stats, or maybe you will have special restrictions on your deck. Completing the quests here will grant you normal card and gold rewards, just like the current quests.
Summary: A "story mode", seperate from the main game where you unlock new cards by going forward. Beating a quest unlock the "hard mode" variant of it in the main game, where it behaves just like the current quests do.